Cancer

New targeted cancer drug shows signs of effectiveness in first clinical trial

  A new targeted drug has a good safety profile and has led to responses in some patients with particular genetic characteristics in their tumours. The promising results of a new phase I trial, led by researchers in the Drug Development Unit at The Institute of Cancer Research, London, and our partner hospital The Royal Marsden NHS Foundation Trust, have already…

Study shows connection between common hypertension drug and skin cancer

December 4, 2017 Recently published research from The University of Southern Denmark and the Danish Cancer Society shows a connection between one of the most common medications for hypertension and skin cancer. Once again, Danish researchers set their sights on antihypertensive medicine containing hydrochlorothiazide, in relation to an increased risk for skin cancer. The researchers have previously demonstrated that the…

Study reveals gene linked to metastatic melanoma

December 4, 2017 A study by Craig J. Ceol, PhD, assistant professor of molecular medicine at the University of Massachusetts Medical School, has revealed a protein active during early embryo development called GDF6 plays a primary role in metastatic melanoma. Published in the Journal of Clinical Investigation by Dr. Ceol, first author Arvind Venkatesan, a PhD candidate at UMMS, and…

Quick, cheap genetic test could help prostate cancer treatment

  Prostate cancer cells. Credit: Mateus Crespo/Prof Johann de Bono, the ICR) Identifying which men with advanced prostate cancer will benefit from targeted treatments could be made easier with a quick and cost-effective test, researchers have found. The test looks for genomic errors in cancer cells that impede their ability to repair broken DNA – and make them sensitive to some…

Researchers refine method to improve early detection of ovarian cancer

December 1, 2017 Researchers at Rice University and the University of Texas MD Anderson Cancer Center have refined and, for the first time, run in vivo tests of a method that may allow nanotube-based probes to locate specific tumors in the body. Their ability to pinpoint tumors with submillimeter accuracy could eventually improve early detection and treatment of ovarian cancer.…

Scientists identifies new genetic changes that increase risk of developing Hodgkin lymphoma

December 1, 2017 People who inherit genetic changes which alter the function of their immune system are at increased risk of developing Hodgkin lymphoma, a major new study reports. Scientists at The Institute of Cancer Research, London, identified six new genetic changes that increase the risk of developing Hodgkin lymphoma – one of the most common cancers in young adults.…

Researchers ID bacteria tied to esophageal cancer

Researchers at NYU Langone Health’s Perlmutter Cancer Center report that at least three kinds of bacteria in the mouths of Americans may heighten or lower their risk of developing esophageal cancer. Publishing online Dec. 1 in the journal Cancer Research, an analysis of data from two national studies involving more than 120,000 patients finds a 21 percent increased cancer risk…

Researchers Make Knockout Stem Cell Lines in One Step

Plasmids encoding reprogramming factors and plasmids encoding gene-editing machinery are transfected together into fibroblast cells. Approximately three weeks later, induced pluripotent stem cell (iPSC) colonies grown from single cells are apparent. These clones can be individually picked from the dish for further isolated growth and study.See full infographic: WEB© GEORGE RETSECK In theory, mutating a gene of interest inside stem…

Low Testosterone Men Less Likely to Have Prostate Cancer

Prostate cancer affects more than 170,000 men each year in the USA, of who almost 30,000 die from the disease….

Genetic Risk Factors for Breast Cancer Identified

Researchers identify 72 novel genetic variants associated with breast cancer risk. Source: New feed
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